The effect of sodium monofluoroacetate on plasma testosterone concentration in Tiliqua rugosa (Gray).
Comparative biochemistry and physiology
Tiliqua rugosa, Sodium monofluoroacetate, Plasma testosterone
Administration of multiple or single doses of sodium fluoroacetate (1080) to male Tiliqua rugosa caused a decrease in plasma testosterone concentration.
A single dose of 100 or 250 mg 1080 kg body weight decreased plasma testosterone by 52%. However, 25 mg kg had a little apparent effect on testosterone levels. When lizards are given the multiple doses equivalent of those doses of over 12 days at 3 day intervals, the effect was much less dramatic with plasma testosterone concentration steadily declining over 15 days for the two higher doses.
There was a suggestion of degeneration of seminiferous tubules in some individuals.
Twigg, L E, King, D R, and Bradley, A J. (1987), The effect of sodium monofluoroacetate on plasma testosterone concentration in Tiliqua rugosa (Gray).. Comparative biochemistry and physiology, Vol. 91C (No. 2), 343-347.